Program
Program Schedule
Venue: <1>Hitotsubashi Memorial Hall(2F)
<2>Conference Room(2F)
<3>Room101-103(1F)
October 22 (Wednesday)
9:00- Registration and information desk open
Opening
10:00-10:10 Opening Remarks : President of The CBI society
Takatoshi Kawai (Eizai Co., Ltd.)
<1>
10:10-10:20 Opening Speech : Chairman of The 2008 Annual Meeting
Yasushi Okazaki (Saitama Medical University)
K1: Keynote - Nuclear Receptors and Metabolic Syndrome
     <Chair>Tatsuo Suda (Saitama Medical University)
10:20-11:20 Yasuo Kagawa (Kagawa Nutrition University)
"Nuclear Receptors and Metabolic Syndrome"
<1>
L1: Technical Luncheon Seminar
11:40-12:40 Technical Luncheon Seminar by FUJITSU LIMITED <3>
S1: Nuclear Receptors & Metabolic Syndrome, Selected Topics
     <Chair>Satoshi Inoue (The University of Tokyo),
               Bruce Blumberg (University of California, Irvine)
13:20-13:55 Barry Forman(The Beckman Research Institute at The City of Hope National Medical Center) >>references
"Bile acids and metabolic signaling: the fast track"
<1>
13:55-14:30 Satoshi Inoue (The University of Tokyo)
"New Target Genes for Steroid Hormones"
14:30-15:00     -Coffee Break-
15:00-15:35 Heonjoong Kang (Seoul National University) >>references
"Ligands of Nuclear Receptors, Novel Drug Leads to Treat Metabolic Syndrome"
15:35-16:10 Makoto Makishima (Nihon University School of Medicine) >>references
"Targeting of the vitamin D receptor, a nuclear receptor acting as an endocrine receptor and a metabolic sensor"
Poster Session
16:30-17:30 Poster Session: Duty Time(odds#) <2>

October 23 (Thursday)
9:00- Registration and information desk open
S2 : e-ADME/Tox : Nuclear Receptors & Related Transcription Factors
     <Chair>Tsuyoshi Yokoi (Kanazawa University),
               Sean Ekins (Collaborations in Chemi. and Univ. of Maryland)
  9:30-10:05 Sean Ekins(Collaborations in Chemistry and University of Maryland) >>references
"Computational Models for PXR and Other Nuclear Hormone Receptors"
<1>
10:05-10:40 Bruce Blumberg(University of California, Irvine) >>references
"Organotins are potent inducers of vertebrate adipogenesis: the case for obesogens"
10:40-11:15 Masahiko Negishi(The National Institute of Environmental Health Sciences) >>references
"Integrating vitamin, nutrient and drug metabolism; new roles for the nuclear xenobiotic receptors CAR and PXR"
11:15-11:50 Masayuki Yamamoto (Tohoku University) >>references
"The Nrf2-Keap1 Stress Response System"
L2 : Luncheon Seminar <Sponsored by Takeda Pharmaceutical Co., Ltd>
     <Chair>Satoshi Inoue (The University of Tokyo)
12:00-13:00 Takashi Kadowaki (The University of Tokyo) >>references
"Molecular Mechanism and Genetic Susceptibility of Type 2 Diabetes and Metabolic Syndrome and Perspective of Tailor-made Medicine"
<1>
13:00-14:00 Lunch <3>
SL1: Special Lecture
     <Chair>Takatoshi Kawai (Eizai Co., Ltd.)
14:00-14:50 Yoshihide Hayashizaki (RIKEN Omics Science Center) >>references
"The new phase of transcriptome analysis"
<1>
S3 : Omics & Pathway/Network to Metabolic Syndrome & Related Disease
     <Chair>Yasushi Okazaki (Saitama Medical University),
               Matthias ReussiUniversity of Stuttgartj
14:50-15:25 Yasushi Okazaki (Saitama Medical University)>>references
"Systematic Analysis of Cross Talk and Pathway in the Differentiation Network of Fat Cells and Osteoblasts"
<1>
15:25-16:00 Vincent Laudet (Ecole Normale Superieure de Lyon, Institute of Functional Genomics) >>references
"Nuclear Hormone Receptor Superfamily: from comparative genomics to evolution"
16:00-16:20     -Coffee Break-
16:20-16:55 Matthias Reuss (University of Stuttgart) >>references
"A quantitative understanding of dynamic cellular processes during detoxification in human hepatocytes"
16:55-17:30 Tatsuhiko Kodama (The University of Tokyo) >>references
"Proteomic and epigenomic analysis of nuclear hormone receptor signaling pathways using monoclonal antibodies against 48 nuclear hormone receptors"
Poster Session
17:30-18:30 Poster Session: Duty Time(even#) <2>
Dining Party
18:30- Dining Party (Buffet style) <3>

October 24 (Friday)
9:00- Registration and information desk open
S4 : Selective NR Modulator
     <Chair>Shigenori Tanaka (Kobe University),
               Ruben Abagyan (The Scripps Research Institute)
  9:30-10:05 Ruben Abagyan (The Scripps Research Institute, Molecular Biology) >>references
"Structural basis of binding and selectivity of nuclear receptor modulators"
<1>
10:05-10:40 Geoffrey L. Greene (The University of Chicago) >>references
"The Molecular Basis of SERM Behavior"
10:40-11:15 Sunil Nagpal (Wyeth Research) >>references
"Liver X Receptor is a Novel Therapeutic Target for Skin Aging"
L3 : Luncheon Seminar <Sponsored by Chugai Pharmaceutical Co., Ltd>
     <Chair>Masami Muramatsu (Saitama Medical University)
11:30-12:30 Shigeaki Kato (The University of Tokyo) >>references
"1alfa, 25(OH)2D3-induced transrepression by VDR on the human CYP27B1 gene promoter mediates the DNA methylation"
<1>
12:30-13:30 Lunch <3>
S5 : Emerging Targets for Metabolic Syndrome
     <Chair>Mitsuhiro Watanabe (Keio University)
13:30-14:05 Lecture of Prof. Johan Auwerx is cancelled and Prof. Mitsuhiro Watanabe will take his part on behalf.

Mitsuhiro Watanabe (Keio University)
"Bile acid signaling in the control of metabolism"
<1>
14:05-14:40 Yoshihiro Ogawa (Tokyo Medical and Dental University) >>references
"Adipose tissue remodeling"
14:40-15:10     -Coffee Break-
15:10-15:45 Jun Nakae (Keio University)
"A novel dual repressor regulates insulin sensitivity through interaction with FoxO1 and TORC2"
15:45-16:20 Peter Tontonoz (University of California, Los Angeles) >>references
"LXR signaling couples sterol metabolism to proliferation in the acquired immune response"
Closing Remarks
16:30- Poster Award <1>
Closing remarks