CBI Annual Meeting 2020 Online

<Japanese>     >Oct. 27(Tue)
    >Oct. 28(Wed)
    >Oct. 29(Thu)
    >Oct. 30(Fri)
(Update 2020.10.26)


Oct. 27(Tue) Oct. 27(Tue) Oct. 27(Tue)


Time CH1 CH2 CH3 CH4 CH5    
10:00-10:10 Opening Remarks            
10:10-10:30 <Conference Chairperson>
Chair: Shinichi Katakura(Keio University)
K-01 Toru Natsume (AIST)
"LabDroid:all purpose humanoid robot for life science"
10:30-12:00 <Plenary Lecture>
Chair: Shinichi Katakura(Keio University)
K-02 Koichi Takahashi(RIKEN)
"Accelerating life sciences by robotic biology"
K-03 Shigeki Tanishima (Mitsubishi Space Software)
"Insight into molecular classification by real world cancer precision medicine database"
13:00-14:30 <Enterprise Session>
World Fusion Co., Ltd.
<Enterprise Session>
Dotmatics Ltd
<Enterprise Session>
Patcore, Inc.
<Enterprise Session>
Bruker Japan K.K.
<Enterprise Session>
DKSH Japan K.K.
14:45-16:15 <Invited Talk>
Chair: Toutai Mitsuyama (AIST)
I-01 Masahiro Kino-oka (Osaka University)
"Technology for cell manufacturing"
I-02 Tomohisa Hasunuma (Kobe University)
"Construction of microbial smart cells by development of high-throughput platform contributing to metabolic design"
I-03 Masahiro Ueda (Osaka University/RIKEN)
"Automated single-molecule imaging analysis and its applications to cell signaling"
Japan Aerospace Exploration Agency(JAXA)

Japan Agency for Medical Research and Development(AMED)

"Initiatives of AMED-BINDS for the drug discovery of COVID-19 infectious disease"
<Focused Session>
Advanced Measurement and Analysis
<Focused Session>
Origin of Life: Chemical Reactions and Information
16:30-18:00 <Invited Talk>
Chair: Midori Kamimura (Teijin Pharma Limited)
I-04 Osamu Nureki (The University of Tokyo)
"Molecular mechanisms of membrane proteins revealed by Cryo-EM analysis"
I-05 Yuji Sugita (RIKEN)
"How cellular environments affect protein structure, dynamics, and functions ?"

<Sponsored Session>
Amazon Web Services Japan K.K.
"Research activities for supporting drug discovery by in-silico unit of BINDS (AMED)"
<Focused Session>
Advanced Measurement and Analysis
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Oct. 28(Wed) Oct. 28(Wed) Oct. 28(Wed)


Time CH1 CH2 CH3 CH4 CH5    
10:00-12:00 <Plenary Lecture>
Chair: Koichi Takahashi (RIKEN)
K-04 Tamio Tanikawa (AIST)
"AI and Robotics to achieve Smart LAB"
K-05 Teruki Honma (RIKEN)
"LINC 3-year challenges and issues to be solved for post LINC"
K-06 Ryo Yoshida (The Institute of Statistical Mathematics)
"Materials Informatics: machine learning for automated materials design and synthesis"
13:00-14:30 <Enterprise Session>
<Enterprise Session>
Elix, Inc.
<Enterprise Session>
<Enterprise Session>
Dassault Systemes K.K.
14:45-16:15 <Invited Talk>
Chair: Teruki Honma (RIKEN)
I-06 Hiroki Shirai (Astellas Pharma Co., Ltd.)
"Machine learning for antibody structure prediction"
I-07 Mari Ito (National Institutes of Biomedical Innovation, Health and Nutrition)
"Drug discovery research using AI: Challenge to automatic collection of clinical information and knowledge processing"
I-08 Haruka Ozaki (University of Tsukuba)
"Description of NGS data analysis workflows towards laboratory automation"
<Sponsored Session>
Fujitsu Limited
"AI-based Substance Hazard Integrated Prediction System (AI-SHIPS) Project" (The Ministry of Economy, Trade and Industry, Research and Development)
<Focused Session>
Neutron Probing Dynamics of Biomolecules, from Hydrogen at Active Site to Domain Correlation
16:30-18:00 <Sponsored Session>
National Institutes of Biomedical Innovation, Health and Nutrition(NIBIOHN) / Life Intelligence Consortium(LINC)
"Development of in vitro human body/tissue-mimicking model using high functional cell devices - Consideration for pharmacokinetic-oriented applications -"
<Focused Session>
"Omics Principles" Committee
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Oct. 29(Thu) Oct. 29(Thu) Oct. 29(Thu)


Time CH1 CH2 CH3 CH4 CH5    
10:00-11:30 <Invited Talk>
Chair: Tsukasa Ishihara (AIST)
I-09 Shinichiro Fuse (Nagoya University)
"Innovation of drug development based on micro-flow and automated synthesis"
I-10 Kanta Ono(High Energy Accelerator Research Organization, KEK)
"Optimization and automation of quantum beam experiments"
I-11 Kazunari Kaizu (RIKEN)
"How to automate modeling of cells?"
I-12 Yusuke Yamada (High Energy Accelerator Research Organization, KEK)
"Automation of macromolecular crystallography experiments in Structural Biology Research Center, KEK"
"Introduction of GENESIS functions relevant for drug discovery"
<Sponsored Session>
OpenEye Japan Co., Ltd.
22th FMO seminar  " Introduction of FMO database and analysis tutorial"
11:45-13:15 <Enterprise Session>
<Enterprise Session>
<Enterprise Session>
Amazon Web Services Japan K.K.
<Enterprise Session>
G-Search Limited
13:30-15:30 <Plenary Lecture>
Chair: Akihiko Konagaya (Keisen University)
K-07 Hiroshi Tanaka (Emeritus Professor, Tokyo Medical and Dental University /Tohoku Medical Megabank Organization)
"Digital Health:Innovation by digital therapeutics"
K-08 Hiroyuki Kobayashi (Shionogi & Co., Ltd.)
"Challenges Facing Today’s Healthcare Industry and Taking on New Phases"
K-09 Ryo Shimizu (Mitsubishi Tanabe Pharma Corp.)
"Digital Medicine at Mitsubishi Tanabe Pharma Corp."

15:45-17:15 <Oral Presentation 1>
Clinical application/Regulatory Science

Chair:Seiichi Ishida (Sojo University)
O1-01 Mashiro Okunaka (Meiji Pharmaceutical University / National Cancer Center Hospital East)
"Evaluation of the expression profile of diarrhea induced by irinotecan using the Japanese Adverse Drug Event Report Database"
O1-02 Kaoru Sato (Lab Neuropharmacol, Div Pharmacol, NIHS)
"Development of in vitro Blood Brain Barrier model reproducing microglia-induced cytokine/chemokine dynamics"
O1-03 Shinichiro Horiuchi (National Institute of Health Sciences)
"Establishment of culture protocol for application of human iPS cell-derived hepatocytes to cholestasis toxicity test"
O1-04 Yukie Kuroda (National Institute of Health Sciences)
"Long term culture using hepatocytes from chimeric mice with humanized livers for toxicity tests"
<Oral Presentation 2>
Drug Discovery application

Chair: Teruki Honma (RIKEN)
O2-01 Hiroshi Kawai (Socium Inc.)
"Phenotypic Network Screening: A New High Throughput Screening Platform"
O2-02 Daiki Erikawa (Tokyo Institute of Technology, School of Computing)
"Development of Monte Carlo Tree Search Based small organic compound generation system"
O2-03 Akihiro Masuda (Department of Biological Sciences, Graduate School of Science and Engineering, Chuo University)
"Development of SSDB software for reproducing the ChEMBL database and its current status"
O2-04 Tamio Mizukami (Nagahama Institute of Bio-Science and Technology)
"Development of new AI-based cell visualization technology that can solve problems in drug discovery and regenerative medicine"
<Oral Presentation 3>
Molecular robotics

Chair: Yusuke Sato (Tohoku University)
O3-01 Nathanael Aubert-Kato (Ochanomizu University)
"Automated exploration of CRN generating DNA structures"
O3-02 Shuntaro Sato (School of Life Science and Technology, Tokyo Institute of Technology)
"Optimization of the multi-step DNA computing reaction using oxDNA MD simulation"
O3-03 Ibuki Kawamata (Tohoku University, Ochanomizu University)
"Analysis of wireframe DNA nanostructure based on coarse-grained molecular dynamics simulated on a web server with simple interface"
O3-04 Taisei Mori (Tohoku University)
"Simulation of Self-replication System with Virtual Spring Model"
17:30-19:00 <Oral Presentation 4>
Structural Bioscience

Chair: Midori Kamimura (Teijin Pharma Limited)
O1-05 Sandhya Tiwari (RIKEN Center for Computational Science)
"Protocol for Assessing the Optimal Pixel Size to Improve the Accuracy of Single-Particle Cryo-Electron Microscopy Maps"
O1-06 Yohta Fukuda (Graduate School of Pharmaceutical Science, Osaka University)
"High-resolution neutron crystallography visualizes an OH-bound resting state of a copper-containing nitrite reductase"
O1-07 Ken Morishima (Institute for Integrated Radiation and Nuclear Science, Kyoto University)
"Innovative Small-Angle Scattering for Structural Analysis of Biomacromolecule in Solution"
<Oral Presentation 5>
Drug Discovery application

Chair: Masakazu Sekijima (Tokyo Institute of Technology)
O2-05 Taro Kakuzaki (Chugai Pharmaceuticals, Co., Ltd.)
"Deep generative model for designing antibody from antibody library data"
O2-06 Eri Wakai (Department of Integrative Pharmacology, Mie University Graduate School of Medicine)
"Search for preventive drugs against Cisplatin-induced nephrotoxicity using public database and electronic medical records."
O2-07 Takahiro Niimura (Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences)
"Search for preventive drugs for drug-induced neuropathy using medical information database"
<Oral Presentation 6>
Molecular robotics/Computational Chemistry (Molecular Recognition)

Chair: Ibuki Kawamata (Tohoku University), Kaori Fukuzawa (Hoshi University), Takatsugu Hirokawa (AIST)
O3-05 Nicolas Lobato-Dauzier (Institute of Industrial Science, The University of Tokyo)
"Temperature-based inputs for molecular reservoir computers"
O3-06 Leo Cazenille (Department of Information Sciences, Ochanomizu University, Tokyo, Japan)
"Exploring Self-Assembling Behaviors in a Swarm of Bio-micro-robots using Surrogate-Assisted MAP-Elites"
O3-07 Yuma Handa (School of Pharmacy and Pharmaceutical Sciences, Hoshi University)
"Prediction of Binding of Existing Drugs to SARS-CoV-2 Main Protease Using Molecular Dynamics and Fragment Molecular Orbital Calculations"
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Oct. 30(Fri) Oct. 30(Fri) Oct. 30(Fri)


Time CH1 CH2 CH3 CH4 CH5    
10:00-12:00 <Plenary Lecture>
Chair: Midori Kamimura (Teijin Pharma Limited)
K-10 Shingo Iwami (Kyushu University)
"Mathematical Sciences in COVID-19"
K-11 Satoshi Matsuoka (RIKEN)
"Fugaku: Applications-First "Exascale" Supercomputer and its Fight Against the COVID-19."
K-12 Keita Komatsu (Cabinet Office, Government of Japan)
"Utilization of Large-Scale Medical Information Data for R&D -Next-Generation Medical Information Infrastructure Act-"
12:00-12:15 The next year introduction            
13:00-14:30 <Oral Presentation 7>
Drug Discovery/Clinical application (Focused on COVID-19)

Chair: Shinichi Katakura (Keio University), Kaori Fukuzawa (Hoshi University), Takatsugu Hirokawa (AIST)
O1-08 Ryo Hatada (Department of Chemistry & Research Center for Smart Molecules, Faculty of Science, Rikkyo University)
"Interaction analyses between SARS-CoV-2 main protease and inhibitor N3 by using fragment molecular orbital method and molecular dynamics simulation"
O1-09 Kazuki Akisawa (Department of Chemistry & Research Center for Smart Molecules, Faculty of Science,Rikkyo University)
"Interaction analyses on SARS-CoV-2 spike proteins by using fragment molecular orbital method"
O1-10 Nazim Medzhidov (Elix, Inc.)
"Predicting inhibitors for SARS-CoV-2 RNA- dependent RNA polymerase using machine learning"
O1-11 Mohini Yadav (Department of Engineering, Chiba Institute of Technology)
"Theoretical insights into the molecular mechanism of NA-I117V-Mediated Oseltamivir Resistance in H5N1 Avian Influenza Virus"
<Oral Presentation 8>

Chair: Takashi Mizuma (Teikyo Heisei University)
O2-08 Yusuke Hoshino (Chiba University)
"The prediction of food effect on drug oral absorption by machine learning"
O2-09 Mizuki Nakamori (Graduate School of Pharmaceutical Sciences, Nagoya City University)
"Prediction of the inhibitory activity of rat drug-metabolizing enzyme by in silico method"
O2-10 Daitaro Misawa (SyntheticGestalt)
"Introduction to the Issues of Dataset Construction in Pharmacokinetic Models"
O2-11 Tetsuo Kitamura (Nonclinical Research Center, LSI Medience Corporation)
"Analysis of monkey pose estimation using deep learning."
<Oral Presentation 9>

Chair: Soichi Ogishima (Tohoku Medical Megabank Organization, Tohoku University), Kaoru Mogushi (Fujitsu Limited)
O3-08 Shigeyuki Magi (Toho University)
"Systems biological approaches to understand the mechanisms of cancer drug resistance & cardiotoxicity"
O3-09 Satoshi Nagaie (Department of Informatics for Genomic Medicine, Tohoku Medical Megabank Organization, Tohoku University)
"Development of phenotyping algorithm of type 2 diabetes mellitus: A retrospective claims database analysis"
O3-10 Naoko Kasahara (Department of Informatics for Genomic Medicine, Tohoku Medical Megabank Organization, Tohoku University)
"Integrated Database “dbTMM” with family linkage for stratification of cohort participants toward drug development"
O3-11 Tsuyoshi Esaki (Shiga University)
"Estimation of relationships between chemical substructures and gene expression antibiotic-resistance of bacteria: Adapting canonical correlation analysis for small sample data by gathered features using consensus clustering"

14:45-16:15 <Oral Presentation 10>
Computational Chemistry (Molecular Modeling)

Chair: Takeshi Ishikawa (Kagoshima University)
O1-12 Kentaro Takai (Fujitsu Ltd.)
"Advanced methods to predict properties of cyclic peptides: conformation analysis of peptides cyclized by non-amide bonds"
O1-13 Kei Moritsugu (Yokohama City University)
"Enhanced conformational sampling of cyclic peptide Cyclorasin by coupled Nosé-Hoover equation"
O1-14 Yuji Mochizuki (Department of Chemistry & Research Center for Smart Molecules, Faculty of Science, Rikkyo University & Institute of Industrial Science, University of Tokyo)
"Development status of ABINIT-MP program in 2020"
O1-15 Koji Okuwaki (Faculty of Science, Rikkyo University)
"Development of multiscale FMO-DPD simulations for molecular design"
<Oral Presentation 11>
Data Science/Structure Activity Relationship

Chair: Yoshihiro Uesawa (Meiji Pharmaceutical University), Kotaro Yuta (In Silico Data, Ltd.)
O2-12 Haris Hasic (Department of Computer Science, School of Computing, Tokyo Institute of Technology)
"Single-step Retrosynthesis Prediction based on the Identification of Potential Disconnection Sites"
O2-13 Tomohiro Sato (Center for Biosystems Dynamics Research, RIKEN)
"Deep neural network models to predict ion channel inhibitors with pre-learning of activity information of analogous proteins"
O2-14 Ryota Jin (Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University)
"Statistically estimating life-long progression of chronic disease from the information of short clinical trials"
O2-15 Yasunari Matsuzaka (Department of Medical Molecular Informatics, Meiji Pharmaceutical University)
"Prediction models of peroxisome proliferator-activated receptor-gamma through a deep learning-based QSAR analysis, DeepSnap"
<Oral Presentation 12>

Chair: Yugo Shimizu (Keio University)
O3-12 Satoshi Mizuno (Tohoku Medical Megabank Organization, Tohoku University)
"Development of machine learning based prediction model for hypertensive disorders of pregnancy (HDP)"
O3-13 Kota Fujisawa (Graduate school of Engineering and Science, University of the Ryukyus)
"Selecting the genes related to COVID-19 with PCA-based unsupervised feature extraction"
16:15-16:30 <Closing Remarks>            
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